|
rs17381664
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs17381664
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs774006043
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, LEPR 668 A/G + G/G carriers with a high fat total intake had 3.0 times higher risk of obesity (p = 0.002) and 4.1 times higher risk of hypercholesterolemia (p = 0.001).
|
26365669 |
2015 |
|
rs778114184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we show that the Arg282Ser mutation in APOA5 gene is associated with a significant reduction of TG (-15.5 mg/dl), total (-18.1 mg/dl) and LDL-cholesterol (-14.8 mg/dl) levels in overweight/obese children and adolescents, indicating that indeed this association appears early in life.
|
28927406 |
2017 |
|
rs2047937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified seven potentially pleiotropic loci-rs3759579 (MARK3), rs2178950 (TRPS1), rs1473 (PUM1), rs9825174 (XXYLT1), rs2047937 (ZNF423), rs17277372 (DNM3), and rs335170 (PRDM6)-associated with osteoporosis and obesity.
|
29145611 |
2018 |
|
rs9825174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified seven potentially pleiotropic loci-rs3759579 (MARK3), rs2178950 (TRPS1), rs1473 (PUM1), rs9825174 (XXYLT1), rs2047937 (ZNF423), rs17277372 (DNM3), and rs335170 (PRDM6)-associated with osteoporosis and obesity.
|
29145611 |
2018 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C allele of rs861539 and T allele of rs1799782 Interaction between rs1799782 and obesity and haplotype T- C were all associated with increased PTC risk.
|
30165355 |
2018 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We uncovered a significant association between obesity (body mass index, ≥ 25) and rs25487.
|
24172093 |
2013 |
|
rs9923451
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study on obesity and obesity-related traits.
|
21552555 |
2011 |
|
rs9923451
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study on obesity and obesity-related traits.
|
21552555 |
2011 |
|
rs35034312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three other rare missense variants were found in obese probands, but these did not clearly cosegregate with obesity in family studies and one (P301S), which was found in three unrelated subjects with early-onset obesity, had normal functional properties.
|
16477437 |
2006 |
|
rs553395822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
R228Q was the only coding, non-synonymous variant that was exclusively found in patients, but the variant did not co-segregate with obesity in the three investigated siblings.
|
23104151 |
2013 |
|
rs10010131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004).
|
18853134 |
2008 |
|
rs2441666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only FTO rs9939609 A>T polymorphism was associated with obesity and no association was observed with ADIPOQ rs2441666 G>T and ACE rs4340288 DIP.
|
30416093 |
2019 |
|
rs1802295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of the current study was to analyze the effect of six type II diabetes GWAS loci rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A), and an FTO polymorphism (rs9939609) on obesity.
|
26395551 |
2016 |
|
rs1802295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MAF of G2548A was 42.8% in obese and 30.1% in controls (<i>P</i>=5.7 × 10<sup>-5</sup>), it showed association with weight, body mass index (BMI), waist circumference (WC), high density lipoprotein cholesterol (HDL-c) and leptin, Gln223Arg had MAF 32% in obese and 18.7% in controls (<i>P</i>=5.4 × 10<sup>-6</sup>), it showed association with fasting plasma glucose (FPG) and all lipid traits, Ala54Thr had MAF 42.4% in obese and 33.1% (<i>P</i>=0.002), it showed association with none of the tested parameters. rs9939609 MAF was 26.6%, and showed association with none of the tested parameters. rs1802295 (<i>P</i>=0.002); rs7178572 (<i>P</i>=0.007); rs2028299 (<i>P</i>=0.04); rs4812829 (<i>P</i>=0.02) showed significant while rs3923113 and rs16861329 did not show a significant association (<i>P</i>=0.20 and <i>P</i>=0.3, respectively) with obesity.
|
29752338 |
2018 |
|
rs35400704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To assess the functional equivalence of human VGF(1-615) (hVGF) and mouse VGF(1-617) (mVGF), and to elucidate the function of the VGF C-terminal region in the regulation of energy balance and susceptibility to obesity, we generated humanized VGF knockin mouse models expressing full-length hVGF or a C-terminally deleted human VGF(1-524) (hSNP), encoded by a single nucleotide polymorphism (rs35400704).
|
25675362 |
2015 |
|
rs752907384
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ACE I/D, AT2 C3123A, TGF-β1 T869C, and VEGF T460C polymorphisms can affect susceptibility to obesity or overweight in Korean children.
|
29115082 |
2017 |
|
rs1544410
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance.
|
28617856 |
2017 |
|
rs1544410
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results showed that the VDR SNPs rs731236 (G) (TaqI) and rs1544410 (T) (Bsm-I) minor allele polymorphisms are significantly more frequent in obese individuals (p = 0.009, β = 0.086 and p = 0.028, β = 0.072, respectively).
|
25020064 |
2014 |
|
rs1544410
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association of candidate gene single nucleotide polymorphisms (SNPs), namely FTO (rs9939609) and VDR (rs1544410), with obesity in the UAE population.
|
29343214 |
2018 |
|
rs731236
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Analysis of vitamin D receptor (VDR) TaqI (rs731236; T/C) and fat mass and obesity-associated (FTO) (rs9939609; A/T) [corrected] polymorphisms in 82 obesity subjects and 102 controls showed significant association for VDR TaqI 'T' allele and obesity (OR: 2.07; 1.123-3.816; P=0.019), contributing to an elevated BMI of 3kg/m(2) per risk allele.
|
23103831 |
2013 |
|
rs731236
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results showed that the VDR SNPs rs731236 (G) (TaqI) and rs1544410 (T) (Bsm-I) minor allele polymorphisms are significantly more frequent in obese individuals (p = 0.009, β = 0.086 and p = 0.028, β = 0.072, respectively).
|
25020064 |
2014 |
|
rs12721377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, polymorphisms in the GC (rs2282679, rs4588, rs7041) and VDR (rs12721377) genes were independently associated with obesity and 25OHD3 levels with a clear sex dimorphism.
|
26881316 |
2016 |
|
rs2239179
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interactions between two previously studied VDR polymorphisms (rs7968585 and rs2239179) and 25OHD concentrations on metabolic and cardiovascular disease-related outcomes such as obesity- (body mass index, waist circumference, waist-hip ratio (WHR)), cardiovascular- (systolic and diastolic blood pressure), lipid- (high- and low-density lipoprotein, triglycerides, total cholesterol), inflammatory- (C-reactive protein, fibrinogen, insulin growth factor-1, tissue plasminogen activator) and diabetes- (glycated haemoglobin) related markers were examined in the 1958 British Birth cohort (n up to 5160).
|
24582179 |
2014 |